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Genes and Hormones
The effect of genes and hormones on hair loss
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The actual cause in hair loss with genetic origins is thought to be 5-alpha reductase enzyme which converts the virility hormone testosterone to dihydrotestosterone. Dihydrotestosterone (DHT) acts by binding to androgen receptors on the hair roots. DHT causes the life cycles of hair roots to shorten. With each cycle the hair gets weaker. As the process repeats the skin of the head becomes visible.
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| Conversion of the virility hormone testosterone by 5-alpha reductase enzyme |
Although hormones and enzymes which lead to hair loss are present in everyone, why do some people have hair loss, while others do not?
The answer to this question can be explained by the theory based on the observations specifically in hair surgery in recent years.
– It is known that hair growth is determined before birth. The cause of hair loss is the genetic sensitivity developed by hair follicles against DTH.
– The higher the ratio of DHT to testosterone, the faster the process of hair loss develops. Congenitally determined alpha-reductase enzyme activity and the amount of this enzyme are also determinant factors. Thus, male pattern hair loss is not related to the amount of the virility hormone, but to the level of production of DHT.
– In patients with male pattern hair loss, the number of androgen receptors in the scalp is higher than the normal value.
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